Improving clinical trials for lung transplant patients with chronic dysfunction
Official title: Secondary Analyses to Support the Rational Design of Clinical Trials in Chronic Lung Allograft Dysfunction
Funded at Duke University · NIH-10908264 · Data updated 2026-11-12
This study is looking at lung transplant patients who are dealing with a serious issue called chronic lung allograft dysfunction (CLAD) to better understand how it progresses and to help create improved ways to test new treatments for this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 16, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $201,250 |
| NIH project number | 5R21AI168582-02 |
| Project ID | NIH-10908264 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult lung transplant recipients who are experiencing chronic lung allograft dysfunction.
✕Less likely to help
Patients who are not lung transplant recipients or those without chronic lung allograft dysfunction may not benefit from this research.
What this research studies
This research focuses on chronic lung allograft dysfunction (CLAD), a serious complication that affects lung transplant recipients and leads to significant mortality. The project aims to create a large multicenter cohort of lung transplant patients experiencing CLAD to gather detailed clinical data. By analyzing this data, the researchers hope to identify patterns in CLAD progression and establish better methods for designing clinical trials that can test new therapies. This approach addresses the challenges of current trial designs, which often lack sufficient information and ethical considerations for patients with this progressive condition.
Why it matters
Potential benefit: If successful, this research could lead to improved clinical trial designs and ultimately new therapies for lung transplant patients suffering from CLAD.
How similar studies have gone: Previous research has shown that utilizing large multicenter cohorts can enhance the understanding and treatment of complex conditions like CLAD, indicating a promising approach.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Todd, Jamie Lynn — Duke University
- Study coordinator: Todd, Jamie Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.