Improving clinical trial participation for urban American Indians

Identifying and addressing barriers to clinical trial participation of Urban American Indians by creating a community research worker role

NIH-funded research Circle Clinical, LLC · NIH-11045142

This study is all about making clinical trials more accessible for urban American Indians by understanding their specific challenges and working together to find solutions that honor their culture, so they feel more comfortable participating.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionCircle Clinical, LLC NIH-funded
Lab location1 site (Sioux Falls, United States)
Project IDNIH-11045142 on NIH RePORTER

What this research studies

This project aims to enhance equity in clinical trials by identifying and addressing the barriers that urban American Indians face when considering participation. It will involve engaging with the community to understand their unique challenges through surveys and discussions. A key aspect of the research is the establishment of a Community Research Worker role, which will help build trust and facilitate communication between researchers and potential participants. The findings will be used to develop tailored solutions that respect Indigenous cultural values and promote greater involvement in clinical research.

Who could benefit from this research

Good fit: Ideal candidates for this research are urban American Indians who are interested in participating in clinical trials.

Not a fit: Patients who do not identify as American Indian or those who are not residing in urban areas may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to increased representation of urban American Indians in clinical trials, ultimately improving health outcomes for this population.

How similar studies have performed: While efforts to improve representation in clinical trials have been made, this specific approach of utilizing a Community Research Worker role is innovative and has not been widely tested.

Where this research is happening

Sioux Falls, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.