Improving clinical trial designs for eye diseases
Unified group sequential designs for clustered data (eye level) in randomized eye trials
This study is working on better ways to design clinical trials for eye diseases so that both eyes are considered together, which could help create more reliable results and ultimately lead to better treatments for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10682609 on NIH RePORTER |
What this research studies
This research focuses on enhancing the design of clinical trials for eye diseases by developing a unified approach that accounts for the correlation between both eyes of a patient. It aims to create statistical methods that allow for interim monitoring of trials, which is crucial for ensuring accurate results and maintaining the integrity of the study. By collaborating with experts from George Washington University and Wills Eye Hospital, the project seeks to evaluate various design options that can be used in trials involving eye conditions, ultimately improving the reliability of findings. Patients with eye diseases may benefit from more effective trial designs that lead to better treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with eye diseases, particularly those who may be involved in clinical trials.
Not a fit: Patients without eye diseases or those not participating in clinical trials may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more reliable clinical trials for eye diseases, resulting in improved treatment options for patients.
How similar studies have performed: While group sequential designs are commonly used in clinical trials, this specific approach to account for inter-eye correlation is novel and has not been extensively tested in existing literature.
Where this research is happening
Washington, United States
- George Washington University — Washington, United States (Active)
Researchers
- Principal investigator: Diao, Guoqing — George Washington University
- Study coordinator: Diao, Guoqing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.