Improving chest compressions for newborns with low heart rates during resuscitation
Official title: Optimizing Chest Compressions for Bradycardia during Neonatal Resuscitation
Funded at State University of New York at Buffalo · NIH-11158673 · Data updated 2026-11-12
This study is looking at the best way to give chest compressions to newborns with slow heart rates during resuscitation, to help improve their chances of survival and protect their brains.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | May 1, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $305,303 |
| NIH project number | 5R01HD104909-05 |
| Project ID | NIH-11158673 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns experiencing bradycardia during resuscitation efforts.
✕Less likely to help
Patients who are not newborns or who do not experience bradycardia during resuscitation may not benefit from this research.
What this research studies
This research investigates how to optimize chest compressions for newborns experiencing bradycardia during resuscitation. It aims to determine the most effective heart rate threshold for initiating compressions, focusing on improving blood flow to the brain and heart. By using animal models, the study will evaluate the impact of different heart rate ranges on gas exchange and overall outcomes. The goal is to refine current neonatal resuscitation protocols to enhance survival and reduce brain injury in newborns.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and reduced brain injury in newborns who experience low heart rates during resuscitation.
How similar studies have gone: Previous research has indicated that optimizing resuscitation techniques can significantly improve outcomes in neonatal care, suggesting potential success for this approach.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Chandrasekharan, Praveen — State University of New York at Buffalo
- Study coordinator: Chandrasekharan, Praveen
Related research
Other NIH-funded projects on the same topics.
-
SPIKE FLOW endocardial pacing lead safety and performance study
This study tests whether the SPIKE FLOW temporary endocardial pacing lead is safe and effective in adults needing temporary pacing during heart-related conditions.
-
Factors Linked to Slow Heart Rate After Pulsed Field Ablation for Atrial Fibrillation
This study looks for factors that might cause bradycardia during the hospital stay after AF ablation using pulsed field technology.
-
Transjugular implantation of a leadless pacemaker (Aveir VR) for ventricular pacing
This study tests whether placing an Aveir VR leadless pacemaker through the neck vein can safely provide ventricular pacing in adults with bradycardia.
-
Conduction System Pacing Display Research During LBBAP Implant
Researchers are testing a CSP Display System during left bundle branch area pacing pacemaker implant to see if it accurately shows heart signals compared with a standard ECG.
-
Focal Cryoablation vs. Radiofrequency Cardioneuroablation for Bradyarrhythmias
This study tests whether focal cryoablation can treat vagally driven slow heart rhythms as well as traditional radiofrequency ablation in adults with bradycardia or related syncope.
-
Personalized pacing rate to see if higher lower rate helps heart and brain flow
In hypertensive patients with bradycardia who need a dual-chamber pacemaker, the study tests whether setting a higher, personalized pacing rate improves heart function and brain blood flow compared with the standard 60 bpm.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.