Improving cerebrospinal fluid balance in hydrocephalus
Modulation of Choroid Plexus Immuno-secretory Function to Restore Cerebrospinal Fluid Homeostasis in Hydrocephalus
This study is looking at how a part of the brain called the choroid plexus controls the fluid around the brain and how we might be able to use this knowledge to help people with hydrocephalus, especially after issues like brain bleeding or infections, without needing surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10808500 on NIH RePORTER |
What this research studies
This research investigates how the choroid plexus, a structure in the brain, regulates the secretion of cerebrospinal fluid (CSF) and how this process can be modulated to treat hydrocephalus without surgery. The study aims to understand the inflammatory responses in the choroid plexus that occur after brain hemorrhages or infections, which can lead to excessive CSF production. By exploring specific molecular pathways and potential drug targets, the research seeks to develop new therapeutic strategies that could prevent or reduce the severity of hydrocephalus.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with hydrocephalus, particularly those who have experienced intraventricular hemorrhage or infections.
Not a fit: Patients with hydrocephalus who are not experiencing inflammation or those who have already undergone surgical interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to non-surgical treatments for hydrocephalus, significantly improving patient outcomes and reducing the need for invasive procedures.
How similar studies have performed: Previous research has shown promise in targeting similar pathways for treating hydrocephalus, indicating that this approach could be a meaningful advancement in the field.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kahle, Kristopher — Massachusetts General Hospital
- Study coordinator: Kahle, Kristopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.