Improving cell therapy for pancreatic cancer
Official title: Using Single-cell and Spatial Multi-omics to Improve Adoptive Cell Therapy against Pancreatic Cancer
Funded at Fred Hutchinson Cancer Center · NIH-10949316 · Data updated 2026-11-12
This study is looking at ways to make T cell therapy work better for people with pancreatic cancer by understanding why T cells sometimes don’t function well in this type of tumor, using advanced techniques to find solutions that could help improve treatment results.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $169,344 |
| NIH project number | 1K99CA293142-01 |
| Project ID | NIH-10949316 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic cancer who are considering or undergoing adoptive T cell therapy.
✕Less likely to help
Patients with other types of cancers or those who are not eligible for adoptive T cell therapy may not benefit from this research.
What this research studies
This research investigates how to enhance the effectiveness of adoptive T cell therapy (ACT) for pancreatic cancer, a solid tumor where current treatments have struggled. By examining the molecular programming of T cells and the tumor microenvironment, the study aims to identify factors that cause T cell dysfunction. Using advanced techniques like single-cell multi-omics and spatial omics, researchers will analyze both mouse models and data from pancreatic cancer patients to uncover targetable mechanisms that could improve therapy outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pancreatic cancer, potentially improving survival rates and quality of life for patients.
How similar studies have gone: Previous research has shown promise in enhancing adoptive T cell therapy for blood cancers, but this approach for solid tumors like pancreatic cancer is still largely untested.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Su, Yapeng — Fred Hutchinson Cancer Center
- Study coordinator: Su, Yapeng
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.