Improving cell therapy for advanced prostate cancer treatment
Optimizing Cell Therapy to Counter Adaptive Resistance Mechanisms in Prostate Cancer
This study is looking at new ways to use your own immune cells to fight advanced prostate cancer, especially when it doesn't respond to regular treatments, so you can get a more personalized approach that targets your specific cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Philadelphia VA Medical Center NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10980420 on NIH RePORTER |
What this research studies
This research focuses on enhancing cell therapy techniques to combat advanced prostate cancer, particularly in cases where the cancer has become resistant to standard treatments. The approach involves using engineered T lymphocytes that can specifically target and attack cancer cells. By understanding how tumors adapt to evade immune responses, the research aims to optimize these therapies for better patient outcomes. Patients may receive personalized treatment based on their unique cancer characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult men diagnosed with advanced prostate cancer who have not responded well to traditional therapies.
Not a fit: Patients with early-stage prostate cancer or those whose cancer is not advanced may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for advanced prostate cancer, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promising results with similar CAR T-cell therapies in other cancers, indicating potential for success in prostate cancer as well.
Where this research is happening
Philadelphia, United States
- Philadelphia VA Medical Center — Philadelphia, United States (Active)
Researchers
- Principal investigator: Posey, Avery D. — Philadelphia VA Medical Center
- Study coordinator: Posey, Avery D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.