Improving care for patients with alcohol-related liver disease undergoing liver transplantation
Official title: 1/4-The INTEGRATE Study: Evaluating INTEGRATEd Care to Improve Biopsychosocial Outcomes of Early Liver Transplantation for Alcohol-Associated Liver Disease
Funded at Ut Southwestern Medical Center · NIH-10893472 · Data updated 2026-11-12
This study is looking at how better teamwork in healthcare can help people with liver disease from alcohol use who are getting a liver transplant, by understanding what helps them get referred for the transplant and how different factors in their lives affect their recovery and health afterwards.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2030 |
| Funding year | 2024 |
| Award (this year) | $424,668 |
| NIH project number | 5R01AA030956-02 |
| Project ID | NIH-10893472 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with alcohol-associated liver disease who are being considered for early liver transplantation.
✕Less likely to help
Patients with liver disease not associated with alcohol or those who do not meet the criteria for early liver transplantation may not benefit from this research.
What this research studies
This research investigates how integrated care can enhance the outcomes for patients with alcohol-associated liver disease who are undergoing early liver transplantation. It aims to identify the factors that influence referrals for transplantation and develop models to predict patient outcomes based on biopsychosocial factors. The study will involve a diverse group of patients and will assess the impact of comprehensive care strategies on their recovery and long-term health after transplantation. By focusing on both medical and social aspects of care, the research seeks to improve overall patient well-being.
Why it matters
Potential benefit: If successful, this research could lead to better health outcomes and improved quality of life for patients undergoing liver transplantation due to alcohol-related conditions.
How similar studies have gone: Previous research has shown promising results in integrated care approaches for similar patient populations, indicating potential for success in this study.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Vanwagner, Lisa B — Ut Southwestern Medical Center
- Study coordinator: Vanwagner, Lisa B
Related research
Other NIH-funded projects on the same topics.
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Targeting a specific CD38 form to protect livers from injury after transplant
A new approach tests a selective drug to protect donor livers from injury during transplant, potentially increasing usable organs and improving transplant outcomes.
-
Regulatory dendritic cell therapy to reduce immunosuppressive drugs after liver transplant
A new approach using donor-derived regulatory dendritic cells is being tested to help adults who receive a liver transplant live without relying on traditional immunosuppressive drugs.
-
HOPE liver transplant: reducing infections and cancer risk for HIV-positive recipients
This grant aims to better understand why HIV-positive liver transplant recipients face higher infection and cancer risks and to improve safety and outcomes for these patients.
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Early liver transplant decisions for severe alcohol-related liver disease
A large study follows adults with severe alcohol-related liver disease to understand how to best select and manage patients for early liver transplantation.
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Early Liver Transplant for Severe Alcoholic Hepatitis
A hospital-based program is studying whether offering an early liver transplant to patients with severe alcoholic hepatitis can save lives when standard medical treatment fails.
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Early liver transplant for severe alcoholic hepatitis (SAH) to save lives
A Johns Hopkins program is testing whether giving an early liver transplant to patients with severe alcoholic hepatitis who can’t be helped by standard treatments can save lives and reduce relapse risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.