Improving CAR T cell therapy for solid tumors
Deconvoluting CAR T cell heterogeneity to engineer durable antitumor protection
This study is looking at ways to make CAR T cell therapy work better for people with solid tumors by tweaking the cells to help them survive in tough conditions, so patients can have a more effective treatment and hopefully better results against cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11037383 on NIH RePORTER |
What this research studies
This research investigates how to enhance the effectiveness of CAR T cell therapy, particularly for patients with solid tumors. The approach involves modifying CAR T cells with growth factors and inflammatory cytokines to help them survive and thrive in the challenging tumor microenvironment. By analyzing the characteristics of long-term survivors and optimizing manufacturing conditions, the research aims to create CAR T cells that can provide lasting protection against cancer. Patients may benefit from a more effective treatment option that could lead to better outcomes in solid tumor cases.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors who have not responded well to traditional therapies.
Not a fit: Patients with hematologic tumors may not benefit from this research as it focuses on solid tumors.
Why it matters
Potential benefit: If successful, this research could lead to more effective CAR T cell therapies that provide durable protection against solid tumors.
How similar studies have performed: Other research has shown promise in enhancing CAR T cell therapies, but this specific approach is innovative and aims to address a significant gap in treatment for solid tumors.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Huang, Yina Hsing — Dartmouth College
- Study coordinator: Huang, Yina Hsing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.