Improving CAR T cell therapy for solid tumors
Official title: Deconvoluting CAR T cell heterogeneity to engineer durable antitumor protection
Funded at Dartmouth College · NIH-11037383 · Data updated 2026-11-12
This study is looking at ways to make CAR T cell therapy work better for people with solid tumors by tweaking the cells to help them survive in tough conditions, so patients can have a more effective treatment and hopefully better results against cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $604,627 |
| NIH project number | 1R01CA297297-01 |
| Project ID | NIH-11037383 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with solid tumors who have not responded well to traditional therapies.
✕Less likely to help
Patients with hematologic tumors may not benefit from this research as it focuses on solid tumors.
What this research studies
This research investigates how to enhance the effectiveness of CAR T cell therapy, particularly for patients with solid tumors. The approach involves modifying CAR T cells with growth factors and inflammatory cytokines to help them survive and thrive in the challenging tumor microenvironment. By analyzing the characteristics of long-term survivors and optimizing manufacturing conditions, the research aims to create CAR T cells that can provide lasting protection against cancer. Patients may benefit from a more effective treatment option that could lead to better outcomes in solid tumor cases.
Why it matters
Potential benefit: If successful, this research could lead to more effective CAR T cell therapies that provide durable protection against solid tumors.
How similar studies have gone: Other research has shown promise in enhancing CAR T cell therapies, but this specific approach is innovative and aims to address a significant gap in treatment for solid tumors.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Huang, Yina Hsing — Dartmouth College
- Study coordinator: Huang, Yina Hsing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.