Improving CAR T cell therapy for lung cancer
Official title: Advancing CAR T cell therapy for solid tumors
Funded at Icahn School of Medicine at Mount Sinai · NIH-10914088 · Data updated 2026-11-12
This study is looking at ways to make CAR T cell therapy work better for lung cancer by creating a model that simulates the tumor environment, helping researchers figure out why it struggles with solid tumors and how to improve treatment for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 14, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $422,500 |
| NIH project number | 5DP5OD031828-04 |
| Project ID | NIH-10914088 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with lung cancer who may benefit from advanced immunotherapy treatments.
✕Less likely to help
Patients with blood cancers or those who do not have solid tumors may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing CAR T cell therapy, which has shown success in treating blood cancers, to effectively target solid tumors like lung cancer. The approach involves creating a new model that mimics the tumor environment found in patients, allowing researchers to study why current therapies are less effective against solid tumors. By understanding the challenges posed by the tumor microenvironment, the research aims to develop innovative strategies to improve the effectiveness of CAR T cells in treating lung cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with lung cancer, potentially improving survival rates and quality of life.
How similar studies have gone: While CAR T cell therapy has been successful in treating blood cancers, applying this approach to solid tumors is still largely untested, making this research novel.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Ahmed, Jalal — Icahn School of Medicine at Mount Sinai
- Study coordinator: Ahmed, Jalal
Related research
Other NIH-funded projects on the same topics.
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Remote-controlled PC-CAR T cells for hard-to-treat solid tumors
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Image-guided, flexible CAR T therapy for solid tumors
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Using tumor-targeting viruses to boost CAR T cell treatment for solid tumors
This work aims to help CAR T cell therapy work better for people with solid tumors by combining CAR T cells with cancer-killing viruses that ramp up the immune response.
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Improving CAR T cell therapy for lung and other solid tumors
This project works to make CAR T cell therapy more effective for people with lung and other solid tumors by building realistic tumor models and testing ways to overcome the tumors' immune defenses.
-
Improving CAR T cell therapy for children with solid tumors
This study is testing a new way to make CAR T cell therapy work better for kids with solid tumors by using special T cells that target a protein called B7-H3, and it aims to see how safe and effective these modified cells are in helping children whose tumors haven't responded to other treatments.
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Using oncolytic viruses to enhance CAR T cell therapy for solid tumors
This study is looking at how using special viruses with CAR T cell therapy might help make the treatment work better for people with solid tumors by helping the CAR T cells find and attack the cancer more effectively.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.