Improving CAR T cell therapy for lung cancer
Advancing CAR T cell therapy for solid tumors
This study is looking at ways to make CAR T cell therapy work better for lung cancer by creating a model that simulates the tumor environment, helping researchers figure out why it struggles with solid tumors and how to improve treatment for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10914088 on NIH RePORTER |
What this research studies
This research focuses on enhancing CAR T cell therapy, which has shown success in treating blood cancers, to effectively target solid tumors like lung cancer. The approach involves creating a new model that mimics the tumor environment found in patients, allowing researchers to study why current therapies are less effective against solid tumors. By understanding the challenges posed by the tumor microenvironment, the research aims to develop innovative strategies to improve the effectiveness of CAR T cells in treating lung cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with lung cancer who may benefit from advanced immunotherapy treatments.
Not a fit: Patients with blood cancers or those who do not have solid tumors may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with lung cancer, potentially improving survival rates and quality of life.
How similar studies have performed: While CAR T cell therapy has been successful in treating blood cancers, applying this approach to solid tumors is still largely untested, making this research novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Ahmed, Jalal — Icahn School of Medicine at Mount Sinai
- Study coordinator: Ahmed, Jalal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.