Improving CAR T cell therapy for lung and other solid tumors
Advancing CAR T cell therapy for solid tumors
['FUNDING_OTHER'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11169974
This project works to make CAR T cell therapy more effective for people with lung and other solid tumors by building realistic tumor models and testing ways to overcome the tumors' immune defenses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11169974 on ClinicalTrials.gov |
What this research studies
Researchers will build the first autochthonous solid tumor model that develops in place and mimics the immune-suppressing environment of human lung cancer. They will use this immunocompetent model to observe how CAR T cells behave inside a realistic tumor setting. The team will test new strategies to help CAR T cells persist and kill tumor cells and will identify which tumor and immune cells block CAR T activity. Results are meant to guide therapies that could later move into human trials.
Who could benefit from this research
Good fit: People with lung cancer or other solid tumors that express the targeted antigens and who meet eligibility for future CAR T clinical trials would be the most likely candidates.
Not a fit: Patients whose tumors do not express the targeted antigens or who need immediate standard-of-care treatment are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could enable CAR T therapies to control or shrink solid tumors such as lung cancer.
How similar studies have performed: CAR T cell therapy has been highly successful in B cell leukemias, but prior CAR T attempts in solid tumors have largely failed to produce clear clinical responses, so this work is novel in addressing those specific barriers.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AHMED, JALAL — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: AHMED, JALAL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.