Improving CAR T cell therapy for children with solid tumors
Enhancing B7-H3-CAR T cell therapy for pediatric solid tumors
This study is testing a new way to make CAR T cell therapy work better for kids with solid tumors by using special T cells that target a protein called B7-H3, and it aims to see how safe and effective these modified cells are in helping children whose tumors haven't responded to other treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11035233 on NIH RePORTER |
What this research studies
This research aims to enhance the effectiveness of CAR T cell therapy specifically for pediatric patients suffering from solid tumors. By targeting a protein called B7-H3, which is found in high levels on certain tumors but not on most normal tissues, the study will evaluate the safety and tumor-fighting ability of modified T cells in a clinical trial. The approach includes a Phase I trial to assess how well these engineered T cells can combat relapsed or refractory tumors in children. Additionally, the research will explore the biology of these T cells to further improve their effectiveness.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients with relapsed or refractory solid tumors that express the B7-H3 antigen.
Not a fit: Patients with solid tumors that do not express the B7-H3 antigen may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective treatment option for children with difficult-to-treat solid tumors.
How similar studies have performed: Previous research has shown promising results with CAR T cell therapies targeting other antigens, indicating potential for success with this novel approach.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Derenzo, Christopher C. — St. Jude Children's Research Hospital
- Study coordinator: Derenzo, Christopher C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.