Improving CAR T-cell therapy for children with leukemia
Improving CAR T-cell therapy for Pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL)
This study is looking at a new kind of CAR T-cell therapy for kids with B-cell Acute Lymphoblastic Leukemia (B-ALL) to see if using special donor cells can make the treatment safer and more effective, while also helping the cells stay in the body longer to keep the cancer from coming back.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10807843 on NIH RePORTER |
What this research studies
This research focuses on enhancing CAR T-cell therapy specifically for pediatric patients suffering from B-cell Acute Lymphoblastic Leukemia (B-ALL). The approach involves testing a new type of CAR T-cell product that uses donor memory T-cells to reduce the risk of complications while aiming to improve treatment outcomes. The study will also explore dual-antigen targeting to help maintain remission and enhance the persistence of the CAR T-cells in the body. Patients will be closely monitored through a Phase I clinical trial to gather data on the effectiveness and safety of these innovative therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients under 21 years of age diagnosed with B-cell Acute Lymphoblastic Leukemia.
Not a fit: Patients with other types of leukemia or those over the age of 21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatment options for children with high-risk leukemia.
How similar studies have performed: Previous research has shown promise in CAR T-cell therapies for pediatric leukemia, indicating that this approach has the potential for significant advancements.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Talleur, Aimee C. — St. Jude Children's Research Hospital
- Study coordinator: Talleur, Aimee C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.