Improving CAR T cell therapy for cancer treatment
Label-free imaging of CAR T cell metabolism
This study is looking to make CAR T cell therapies better for cancer patients by using new technology to understand how T cells work, so we can find out which patients will benefit the most and improve the treatment for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Morgridge Institute for Research, INC. NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10895431 on NIH RePORTER |
What this research studies
This research aims to enhance the effectiveness of CAR T cell therapies, which are a promising treatment for certain cancers. The team will develop non-invasive technologies to analyze T cell metabolism at a single-cell level, helping to identify which patients' T cells are suitable for therapy and how to optimize their production. By focusing on improving the quality of T cells used in treatment, the research seeks to overcome current limitations that prevent long-lasting remissions in many patients. The ultimate goal is to ensure that CAR T cell therapies are more potent and effective for cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with B-cell lymphomas who are considering or undergoing CAR T cell therapy.
Not a fit: Patients with cancers other than B-cell lymphomas or those who are not eligible for CAR T cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective CAR T cell therapies, resulting in longer-lasting remissions for cancer patients.
How similar studies have performed: Other research has shown promise in enhancing CAR T cell therapies, but this approach of using non-invasive single-cell technologies is relatively novel.
Where this research is happening
Madison, United States
- Morgridge Institute for Research, INC. — Madison, United States (Active)
Researchers
- Principal investigator: Skala, Melissa Caroline — Morgridge Institute for Research, INC.
- Study coordinator: Skala, Melissa Caroline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.