Improving CAR-T cell therapy for brain tumors using focused ultrasound

Who could benefit from this research

What this research studies

This research investigates how focused ultrasound (FUS) can enhance the effectiveness of CAR-T cell therapy for treating glioblastoma, a type of brain tumor. By using FUS, the researchers aim to temporarily disrupt the blood-brain barrier, allowing CAR-T cells to better penetrate brain tissue and target tumor cells. The study involves advanced biomedical engineering techniques and aims to improve the delivery of these innovative therapies to patients with brain tumors. The approach is based on promising early studies that have shown the potential of FUS in enhancing drug delivery to the brain.

Why it matters

Where this research is happening

• Univ of North Carolina Chapel Hill
  Chapel Hill, United States Active

Researchers

• Principal investigator: Dayton, Paul a — Univ of North Carolina Chapel Hill
• Study coordinator: Dayton, Paul a

Related research

Other NIH-funded projects on the same topics.

• Implantable scaffolds to make CAR‑T therapy stronger and cheaper for brain tumors

  This project aims to use a biocompatible implant placed at the tumor site to help CAR‑T immune cells reach and kill glioblastoma cells while reducing the need for repeated, costly infusions.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11294220

• Developing new scaffolds to improve CAR-T cell therapy for brain tumors

  This study is looking at a new way to make CAR-T cell therapy work better for people with glioblastoma, a tough brain tumor, by using special scaffolds to help deliver the treatment right to the tumor, so patients can get more effective care.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11159094

• Enhancing CAR T cell therapy for brain tumors

  This study is looking at ways to make CAR T cell therapy better for people with high grade gliomas, a tough type of brain tumor, by tweaking the T cells to help them fight the tumor more effectively.

  NIH research Children's Research Institute · Washington, United States · NIH-11001478

• Improving drug delivery to brain tumors using focused ultrasound and vascular normalization

  This study is exploring a new way to help deliver cancer-fighting drugs more effectively to brain tumors by using focused ultrasound and tiny bubbles, which could make treatments work better for patients.

  NIH research University of Virginia · Charlottesville, United States · NIH-10933855

• Modulating deep brain activity with focused ultrasound for cocaine use disorder

  A study will test whether targeting a deep brain region with focused ultrasound can alter brain signals related to craving in people with cocaine use disorder.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11611302

• Dose-Dependent Brain Wire Modulation with Light Ultrasound in Deep White Matter

  A small early study tests whether gentle, noninvasive ultrasound can change how deep brain white matter tracts work in healthy adults.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11596522

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.