Improving CAR T cell therapy for blood cancers by enhancing cell signaling
Increasing the efficacy of non-activated CAR T cells by modulating IFN1 signaling
This study is looking at a new way to make CAR T cell therapy better for people with blood cancers by using special T cells that can last longer and work more effectively, which could help patients have a stronger and longer-lasting response to treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10943418 on NIH RePORTER |
What this research studies
This research focuses on enhancing the effectiveness of CAR T cell therapy, which is used to treat blood cancers. The approach involves using non-activated T cells, which have better characteristics for long-term cancer control compared to activated T cells. The study aims to improve the efficiency of these non-activated T cells by using a specific protein that enhances their ability to be modified and function effectively after infusion. Patients may benefit from a more durable response to treatment as a result of this innovative method.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with blood cancers who are considering CAR T cell therapy.
Not a fit: Patients with solid tumors or those who do not have blood cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and long-lasting CAR T cell therapies for patients with blood cancers.
How similar studies have performed: Previous research has shown promising results with similar approaches to enhancing CAR T cell therapy, indicating potential for success in this study.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Ghassemi, Saba — University of Pennsylvania
- Study coordinator: Ghassemi, Saba
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.