Improving cancer treatment using personalized mouse models
Advancing Precision Oncology in a Humanized, Fully Autologous Mouse Model
This study is creating a special mouse model that has a human immune system to help researchers learn how human cancers react to different treatments, like immunotherapy and vaccines, so they can develop better and more personalized cancer therapies for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10814237 on NIH RePORTER |
What this research studies
This research focuses on developing a unique mouse model that incorporates a complete human immune system to study cancer immunotherapy. By using patient-derived tumors, researchers aim to better understand how human cancers respond to various treatments, including immunotherapy and vaccines. The goal is to create a more accurate pre-clinical environment that reflects human biology, allowing for the evaluation of treatment responses and potential side effects in a controlled setting. This approach could lead to more effective and personalized cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with melanoma, pancreatic, or colorectal tumors who are seeking innovative treatment options.
Not a fit: Patients with cancers not represented in the study, or those who do not have access to the required personalized tumor samples, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments for patients.
How similar studies have performed: Other research has shown promise in using humanized mouse models for studying cancer therapies, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Fields, Ryan C — Washington University
- Study coordinator: Fields, Ryan C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.