Improving cancer treatment matching using advanced 3D tissue models
Label-Free, Longitudinal, Multi-Metric Viability Imaging of 3D Tissue Spheroid Array
This study is looking to improve cancer treatment by using 3D models of tumors to see how well different chemotherapy drugs work, so that patients can get more personalized and effective therapies based on their own cancer cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10880364 on NIH RePORTER |
What this research studies
This research focuses on enhancing the precision of cancer treatment by developing a method that uses 3D tissue models to better mimic the tumor environment. By utilizing advanced imaging techniques, the study aims to assess how different chemotherapy drugs affect cancer cells in a more realistic setting. This approach seeks to overcome the limitations of traditional methods that often fail to provide personalized treatment options. Patients' tumor cells will be tested in these 3D cultures to identify the most effective therapies tailored to their specific cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients whose tumors can be biopsied for testing against various chemotherapy options.
Not a fit: Patients with cancers that do not allow for biopsy or those who are not candidates for chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective cancer treatments for patients.
How similar studies have performed: Similar approaches using 3D cell culture techniques have shown promise in improving treatment matching, indicating potential for success in this research.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Lee, Jonghwan — Brown University
- Study coordinator: Lee, Jonghwan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.