Improving cancer treatment by targeting stress in immune cells
Targeting Chronic ER Stress in T Cells to Improve Cancer Immunotherapy
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10977327
This study is looking at how long-term stress in certain immune cells affects their ability to fight cancer, especially in sarcomas, and aims to find ways to make cancer treatments work better for patients by boosting their immune response.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10977327 on ClinicalTrials.gov |
What this research studies
This research investigates how chronic stress in CD8 T cells affects their ability to fight cancer, particularly in sarcomas. The study focuses on the role of specific proteins that influence T cell function and survival under stress conditions. By understanding these mechanisms, the research aims to enhance the effectiveness of existing cancer immunotherapies, such as PD-1 inhibitors. Patients may benefit from new strategies that improve their immune response to tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sarcomas who are undergoing or considering immunotherapy treatments.
Not a fit: Patients with cancers other than sarcomas or those not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer immunotherapies for patients with sarcomas.
How similar studies have performed: Other research has shown promise in targeting stress responses in immune cells, suggesting potential for success in this approach.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THAXTON, JESSICA E — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: THAXTON, JESSICA E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.