Improving cancer prevention and treatment across NCI clinical networks
Advancing novel cancer preventive and therapeutic strategies across the modern NCI clinical trial networks
This award supports an expert who will strengthen NCI clinical trial networks to bring safer, fairer cancer prevention and treatment options to people with or at risk for cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11182591 on NIH RePORTER |
What this research studies
This funding gives protected time to an experienced leader to improve how clinical trials are designed, run, and completed across NCI-sponsored networks. The work includes leading committees, mentoring junior clinicians, and using new patient recruitment approaches to make trials more diverse and efficient. A central activity is completing the ongoing Phase III S0820/PACES trial testing eflornithine plus sulindac to prevent colon polyps, while also encouraging new prevention and treatment concepts within the network. Overall the focus is on improving trial quality and accessibility so results better inform care for patients.
Who could benefit from this research
Good fit: People with a history of colonic adenomas, those at high risk for colorectal cancer, and patients eligible for NCI network trials would be the most likely candidates for related trials.
Not a fit: Patients with conditions unrelated to the cancers targeted by NCI network trials or those ineligible for NCI trials may not directly benefit from this work.
Why it matters
Potential benefit: If successful, patients could gain access to improved prevention options for colorectal cancer and better-run treatment trials that reach more people.
How similar studies have performed: Previous randomized trials have shown promise for some colorectal adenoma prevention therapies, and this work builds on that evidence while improving trial operations.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Zell, Jason — University of California-Irvine
- Study coordinator: Zell, Jason
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.