Improving cancer immunotherapy by targeting stress in T cells
Targeting Chronic ER Stress in T Cells to Improve Cancer Immunotherapy
This study is looking at how stress in certain immune cells affects their ability to fight sarcoma, a type of cancer, and aims to find ways to make cancer treatments work better for patients by improving their immune response.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10896925 on NIH RePORTER |
What this research studies
This research investigates how chronic endoplasmic reticulum (ER) stress affects CD8 T cells in sarcomas, a type of cancer. It focuses on the role of specific proteins, ATF4 and ERO1a, in determining the fate of these immune cells and their response to immunotherapy. By understanding the mechanisms of stress in T cells, the research aims to enhance the effectiveness of existing cancer treatments, particularly those that target the PD-1 pathway. Patients may benefit from new strategies that improve their immune response against tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sarcomas who are undergoing or considering immunotherapy.
Not a fit: Patients with cancers other than sarcomas or those not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer immunotherapies for patients with sarcomas.
How similar studies have performed: Other research has shown promising results in targeting stress responses in immune cells, suggesting potential for success in this approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Thaxton, Jessica E — Univ of North Carolina Chapel Hill
- Study coordinator: Thaxton, Jessica E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.