Improving cancer immunotherapy by enhancing T cell metabolism
Exploiting a novel regulator of immunometabolism to enhance immunotherapy
This study is looking at ways to make cancer treatments using T cells work better, especially for tough tumors like melanoma, by helping the T cells get the energy they need to fight the cancer more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10890051 on NIH RePORTER |
What this research studies
This research investigates how to improve adoptive T cell therapy for cancer, particularly for solid tumors like melanoma, which often create a challenging environment for T cells. The approach focuses on modifying CD8 T cells to enhance their metabolism, allowing them to thrive in low-nutrient tumor environments. By engineering these T cells to utilize multiple energy sources, the research aims to boost their effectiveness against tumors that have become resistant to current treatments. The study employs advanced techniques such as single-cell transcriptional profiling to understand and enhance T cell function.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors, particularly melanoma, who may benefit from enhanced immunotherapy.
Not a fit: Patients with liquid tumors or those who do not have solid tumors may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with solid tumors, improving their chances of remission.
How similar studies have performed: Other research has shown promise in enhancing T cell metabolism for improved cancer treatment, indicating that this approach could be a significant advancement.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Usherwood, Edward J — Dartmouth College
- Study coordinator: Usherwood, Edward J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.