Improving cancer imaging by correcting for breathing motion
Official title: Personalized Task-Based Respiratory Motion Correction for Low-Dose PET/CT
Funded at Yale University · NIH-10436864 · Data updated 2026-11-12
This study is working on making cancer scans clearer and more accurate by creating special techniques that adjust for how each patient breathes, which can help doctors better see and measure tumors, especially for those who have irregular breathing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 2, 2018 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $628,203 |
| NIH project number | 5R01CA224140-05 |
| Project ID | NIH-10436864 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients undergoing PET/CT imaging, particularly those with irregular breathing patterns.
✕Less likely to help
Patients with stable and regular breathing patterns may not benefit significantly from the personalized motion correction strategies being developed.
What this research studies
This research focuses on enhancing the accuracy of PET/CT imaging for cancer patients by developing personalized motion correction techniques that account for individual breathing patterns. Current methods often fail for patients with irregular breathing, which can lead to inaccurate tumor detection and assessment. By tailoring the correction strategies to each patient's unique breathing characteristics, the study aims to improve the clarity and reliability of imaging results, particularly for those undergoing low-dose PET scans. This approach seeks to minimize image blurring and enhance the quantification of tumors in the lung and abdomen.
Why it matters
Potential benefit: If successful, this research could lead to more accurate cancer diagnoses and treatment evaluations, ultimately improving patient outcomes.
How similar studies have gone: While there have been advancements in motion correction techniques, this personalized approach specifically targeting irregular breathing patterns is relatively novel and has not been extensively tested.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Liu, Chi — Yale University
- Study coordinator: Liu, Chi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.