Improving cancer detection using advanced DNA profiling techniques
Enriching and Base-Resolution Profiling of 5-Methylcytosine in Degraded Clinical Samples
['FUNDING_OTHER'] · UNIVERSITY OF CHICAGO · NIH-11064396
This study is working on a new way to look at DNA changes related to cancer, using a special technique called Glimp-seq that can analyze tiny samples, like those from biopsies or blood tests, to help doctors detect cancer more accurately.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11064396 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the ability to profile 5-methylcytosine (5mC) in clinical samples, which is crucial for understanding and tracking cancer development. It aims to develop a new sequencing platform called Glimp-seq that can analyze degraded DNA from small samples, such as those found in formalin-fixed tissues and cell-free DNA. By utilizing innovative enzymatic reactions, this approach seeks to provide more accurate and sensitive detection of cancer-related changes in the DNA, potentially leading to better diagnostic methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancer or those at high risk of developing cancer, particularly if they have limited or degraded tissue samples available for analysis.
Not a fit: Patients with early-stage cancer who have sufficient high-quality tissue samples may not benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer detection methods, allowing for earlier diagnosis and better treatment options for patients.
How similar studies have performed: Previous research has shown promise in enhancing DNA profiling techniques, but this specific approach using glycosylase-based sequencing is novel and untested.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TANG, WEIXIN — UNIVERSITY OF CHICAGO
- Study coordinator: TANG, WEIXIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer research, Atlas of Cancer Mortality in the United States