Improving breathing support for preterm infants with lung disease
2/2 The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial
This study is looking at a new way to help preterm babies with breathing problems by using a special technology that works with their natural breaths, aiming to keep their lungs healthier and improve their breathing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11001515 on NIH RePORTER |
What this research studies
This research investigates a new method of providing breathing support to preterm infants suffering from chronic lung disease, specifically bronchopulmonary dysplasia (BPD). The approach utilizes a technology called Neurally Adjusted Ventilatory Assist (NAVA) that synchronizes non-invasive ventilation with the infant's natural breathing efforts. By matching the electrical signals from the diaphragm, this method aims to reduce the risk of lung injury associated with traditional ventilation methods. The study will assess the effectiveness of this technique in improving respiratory outcomes for these vulnerable infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are preterm infants who are experiencing respiratory failure and are at risk for developing bronchopulmonary dysplasia.
Not a fit: Patients who are not preterm or do not have respiratory issues related to lung disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of bronchopulmonary dysplasia in preterm infants, leading to better long-term respiratory health.
How similar studies have performed: Previous research has shown that synchronized non-invasive ventilation can reduce the incidence of bronchopulmonary dysplasia, indicating that this approach has potential based on earlier successes.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Ratcliffe, Sarah J — University of Virginia
- Study coordinator: Ratcliffe, Sarah J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.