Improving breathing support for premature infants with lung issues
1/2 The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial
This study is looking at ways to help premature babies with lung problems breathe better without needing more invasive treatments, by comparing two gentle breathing methods to see which one works best for keeping their lungs safe and healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11001838 on NIH RePORTER |
What this research studies
This research focuses on bronchopulmonary dysplasia (BPD), a serious lung condition affecting premature infants. It aims to develop better non-invasive ventilation strategies to reduce the need for invasive mechanical ventilation, which can cause further lung injury. The study will evaluate the effectiveness of synchronized non-invasive positive pressure ventilation (NIPPV) compared to traditional continuous positive airway pressure (CPAP) in preventing extubation failure in preterm infants. By prioritizing lung protection, the research seeks to improve respiratory outcomes and reduce healthcare costs associated with BPD.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants diagnosed with respiratory failure or at risk of developing bronchopulmonary dysplasia.
Not a fit: Patients who are not premature or do not have respiratory complications related to bronchopulmonary dysplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved breathing support methods that enhance recovery and quality of life for premature infants suffering from lung complications.
How similar studies have performed: Previous research has shown that non-invasive positive pressure ventilation techniques can be more effective than traditional methods, indicating a promising avenue for this study.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Foglia, Elizabeth — University of Pennsylvania
- Study coordinator: Foglia, Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.