Improving Breast Cancer Treatment with Personalized Approaches
Project 1: Imaging, pathology, and molecular biomarkers to Optimize Treatment Switching within a SMART adaptive Framework
This research helps doctors find the best breast cancer treatments for each patient, aiming for better results with fewer side effects.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11125943 on NIH RePORTER |
What this research studies
This project is part of the larger I-SPY2 trial, which tests new treatments for breast cancer before surgery. The goal is to understand how each patient responds to therapy so doctors can adjust treatments specifically for them. This means some patients might receive additional helpful therapies, while others might avoid harsh treatments they don't need. Ultimately, this helps personalize care and improve outcomes for people with breast cancer.
Who could benefit from this research
Good fit: Ideal candidates are patients with breast cancer who are undergoing or considering neoadjuvant therapy (treatment before surgery).
Not a fit: Patients without breast cancer or those not receiving neoadjuvant therapy would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more effective and less toxic personalized treatment plans for breast cancer patients.
How similar studies have performed: The I-SPY2 trial has already identified several new therapies that significantly improved patient responses, leading to further large-scale trials.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Demichele, Angela — University of California, San Francisco
- Study coordinator: Demichele, Angela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.