Improving brain tumor imaging using a new glucose metabolism technique
Official title: Single-scan, multi-contrast imaging of glucose metabolism in patients with glioblastoma
Funded at Yale University · NIH-11048491 · Data updated 2026-11-12
This study is testing a new, gentle imaging method to help doctors see how glioblastoma, a tough brain tumor, is changing over time, so they can make better treatment choices for patients without needing lots of MRI scans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 2, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $677,801 |
| NIH project number | 1R01CA288833-01A1 |
| Project ID | NIH-11048491 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who require regular monitoring of tumor growth and treatment response.
✕Less likely to help
Patients with brain tumors other than glioblastoma or those who are not undergoing treatment for their tumors may not benefit from this research.
What this research studies
This research focuses on developing a noninvasive imaging technique to better assess the progression of glioblastoma, an aggressive brain tumor. By using a method called deuterium metabolic imaging (DMI) with non-radioactive deuterated glucose, the study aims to quickly identify tumor activity and growth without the need for multiple MRI scans over time. This approach could provide clinicians with timely information to make more informed treatment decisions for patients. The goal is to enhance the accuracy of brain tumor imaging and improve patient management.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate assessments of glioblastoma progression, ultimately improving treatment outcomes for patients.
How similar studies have gone: While metabolic imaging has shown success in other tumor types, this specific approach for glioblastoma is novel and has not been extensively tested.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: De Feyter, Henk — Yale University
- Study coordinator: De Feyter, Henk
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.