Improving brain stimulation treatments for epilepsy by finding the right patients and timing.
Optimizing Neuromodulation Therapies for Epilepsy: Identifying the Right Patient, Right Place, and Right Time for Stimulation
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11046208
This study is looking to improve a treatment called responsive neurostimulation (RNS) for people with epilepsy that doesn't respond to medication, by figuring out what helps each person get the best results, so you can have a more personalized way to manage your seizures.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11046208 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the effectiveness of responsive neurostimulation (RNS) for patients with drug-resistant epilepsy. It aims to identify key factors that influence how well patients respond to RNS, including brain connectivity, optimal timing for stimulation, and the impact of circadian rhythms on treatment outcomes. By using advanced imaging techniques and patient-specific data, the study seeks to tailor treatments to individual needs, potentially leading to better seizure control. Patients may experience a more personalized approach to their epilepsy management through this innovative research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with epilepsy that does not respond to standard medications, particularly those considering responsive neurostimulation.
Not a fit: Patients with epilepsy that is well-controlled by medication or those who do not qualify for neuromodulation therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients with drug-resistant epilepsy, improving their quality of life.
How similar studies have performed: Previous research has shown promise in using personalized approaches to neuromodulation therapies, indicating potential for success in this novel investigation.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROLSTON, JOHN D — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: ROLSTON, JOHN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.