Improving brain recovery after stroke using blood vessel guidance
Neuroregeneration after stroke using Vascular Guidance
This study is looking at ways to help brain cells that can repair damage after a stroke by making blood vessel cells in the brain better at guiding them to where they need to go, which could lead to improved recovery for stroke patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10986876 on NIH RePORTER |
What this research studies
This research investigates how to enhance the survival and movement of neural progenitor cells (NPCs) in the brain after a stroke. It focuses on reprogramming adult brain blood vessel cells to express genes that can help guide NPCs to the right locations in the brain, improving their ability to survive and function. The study includes detailed experiments to assess how well these NPCs can migrate and differentiate in a post-stroke environment, with the goal of developing new treatment strategies that combine NPC transplantation with improved blood vessel function. If successful, this research could lead to better recovery of cognitive and motor skills for stroke patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced a stroke or other acquired brain injuries.
Not a fit: Patients with conditions unrelated to stroke or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new treatment options that significantly improve recovery outcomes for stroke patients.
How similar studies have performed: Other research has shown promise in using similar approaches to enhance recovery after brain injuries, suggesting potential for success in this novel application.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Thankamani Pandit, Peeyush Kumar — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Thankamani Pandit, Peeyush Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.