Improving brain protection in newborns with oxygen deprivation
Targeting mitochondrial Complex I in neonatal hypoxia-ischemia
This study is looking at how a special drug can help protect the brains of newborns with a serious condition called hypoxic ischemic encephalopathy (HIE) by improving energy use in their brain cells and reducing damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11017725 on NIH RePORTER |
What this research studies
This research focuses on neonatal hypoxic ischemic encephalopathy (HIE), a serious condition that can lead to severe developmental issues in newborns due to lack of oxygen. The study aims to enhance current treatments by targeting mitochondrial Complex I, which plays a crucial role in brain energy metabolism. Using a rodent model, researchers will investigate how a specific drug, mdivi-1, can reduce harmful reactive oxygen species while preserving mitochondrial function. This approach seeks to improve neuroprotection and reduce brain injury in affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborn infants diagnosed with hypoxic ischemic encephalopathy.
Not a fit: Patients who are not newborns or those without a diagnosis of hypoxic ischemic encephalopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that significantly reduce brain damage and enhance recovery in newborns suffering from HIE.
How similar studies have performed: Previous research has shown promising results in targeting mitochondrial dysfunction for neuroprotection, suggesting potential success for this novel approach.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Waddell, Jaylyn Waddell — University of Maryland Baltimore
- Study coordinator: Waddell, Jaylyn Waddell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.