Improving brain oxygen levels in patients with severe traumatic brain injury.
Brain Oxygen Optimization in Severe Traumatic Brain Injury - Phase 3 (BOOST-3)
['FUNDING_U01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10996078
This study is looking at ways to help people who have had a severe brain injury and are in a long coma by keeping a close eye on the oxygen levels in their brain and trying new treatments to improve their recovery and reduce disabilities.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10996078 on ClinicalTrials.gov |
What this research studies
This research focuses on patients who have experienced severe traumatic brain injury (TBI), particularly those in prolonged coma. It aims to improve outcomes by monitoring oxygen levels in the brain tissue and applying interventions to prevent brain tissue hypoxia. The study builds on previous findings that show a strong link between low oxygen levels and poor recovery, and it seeks to determine if targeted treatments based on this monitoring can enhance recovery and reduce disabilities. Patients will be closely monitored in intensive care units to assess the effectiveness of this approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have sustained a severe traumatic brain injury and are experiencing prolonged coma.
Not a fit: Patients with mild traumatic brain injuries or those who are not in a coma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery rates and reduced long-term disabilities for patients with severe TBI.
How similar studies have performed: Previous studies have shown promising results with similar approaches to monitoring brain oxygen levels, indicating potential for significant advancements in treatment.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARSAN, WILLIAM G — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: BARSAN, WILLIAM G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury