Improving brain imaging with advanced fluorescent probes
Official title: Resource for Multiphoton Characterization of Genetically-Encoded Probes
Funded at Montana State University - Bozeman · NIH-11031953 · Data updated 2026-11-12
This study is all about making a special imaging tool better so scientists can see how brain cells work together, and it’s designed to help researchers who are studying the brain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montana State University - Bozeman NIH-funded |
| Lab location | 1 site (Bozeman, United States) |
| Project start | September 30, 2018 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $324,178 |
| NIH project number | 5U24NS109107-07 |
| Project ID | NIH-11031953 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with neurological conditions or those involved in brain research who require advanced imaging techniques.
✕Less likely to help
Patients with conditions unrelated to brain function or those not involved in research settings may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing the capabilities of two-photon laser scanning microscopy, a technique crucial for observing the activity of living neural networks in the brain. It aims to optimize genetically-encoded fluorescent probes and biosensors that are essential for labeling and recording neuronal circuits. By characterizing the multiphoton properties of these probes, the research will identify the best wavelengths for excitation and improve the brightness and dynamic range of biosensors. This work supports a wide range of laboratories involved in brain research, providing them with access to advanced characterization resources.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in brain imaging techniques, improving our understanding of neural networks and potentially aiding in the development of treatments for neurological disorders.
How similar studies have gone: Previous research has shown success in optimizing fluorescent probes for one-photon imaging, but this approach to two-photon characterization is relatively novel and untested.
Where this research is happening
-
Montana State University - Bozeman
Bozeman, United States Active
Researchers
- Principal investigator: Drobizhev, Mikhail — Montana State University - Bozeman
- Study coordinator: Drobizhev, Mikhail
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.