Improving brain imaging techniques to see deeper into the cortex
Direct wavefront sensing and adaptive optics to enable two-photon imaging axons and spines throughout all of cortex
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10819181
This study is working on improving a special type of microscope that helps scientists see the brain's tiny structures more clearly, so they can better understand how brain cells communicate and work together, especially in deeper parts of the brain.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10819181 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing two-photon laser scanning microscopy, a vital tool for observing brain structures and functions at a cellular level. By utilizing adaptive optics, the study aims to correct optical distortions caused by brain tissue, allowing for clearer imaging of synaptic dynamics in deeper layers of the cortex. This advancement will enable researchers to explore previously inaccessible areas of the brain, particularly in understanding how cortical output neurons function. The project also emphasizes sharing knowledge and designs to help other laboratories replicate these improvements.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that affect cortical function or those participating in studies related to brain imaging.
Not a fit: Patients with conditions unrelated to cortical function or those not involved in neuroimaging studies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking insights into brain function and potentially improve treatments for neurological disorders.
How similar studies have performed: Previous research has shown promise in using adaptive optics for improving imaging techniques, indicating a strong potential for success in this novel application.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KLEINFELD, DAVID — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: KLEINFELD, DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.