Improving brain imaging techniques for early detection of Alzheimer's disease.
Methods for Quantitative Neuroimaging of Tau Burden in Pre-symptomatic AD
This study is working on improving brain scans to find tau protein buildup, which can help spot Alzheimer's disease earlier, even before symptoms show up, so that people can get better care and understanding of the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11049091 on NIH RePORTER |
What this research studies
This research focuses on enhancing the imaging methods used to detect tau protein accumulation in the brain, which is crucial for diagnosing Alzheimer's disease before symptoms appear. The team aims to develop advanced technologies that improve the accuracy and resolution of PET imaging, allowing for better localization of tau deposits in specific brain regions. By utilizing structural MRI images and correcting for motion, the researchers hope to create clearer images that can help identify early signs of Alzheimer's. This innovative approach could lead to more effective monitoring and understanding of the disease's progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk for Alzheimer's disease but have not yet shown symptoms.
Not a fit: Patients who are already diagnosed with advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnosis of Alzheimer's disease, allowing for timely interventions.
How similar studies have performed: Other research has shown promise in improving imaging techniques for Alzheimer's, but this specific approach is innovative and largely untested.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: El Fakhri, Georges — Yale University
- Study coordinator: El Fakhri, Georges
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.