Improving brain imaging techniques for better understanding of mental disorders
Harmonizing multi-site diffusion MRI acquisitions for neuroscientific analysis across ages and brain disorders
This study is working on improving brain scans to help researchers better understand how conditions like Alzheimer's affect brain connections, making it easier to compare results from different studies and learn more about changes in the brain as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10553703 on NIH RePORTER |
What this research studies
This research focuses on enhancing diffusion MRI (dMRI) techniques to better analyze brain connections in individuals with mental disorders, particularly Alzheimer's disease. By developing new algorithms, the project aims to harmonize data collected from different MRI scanners, allowing for more accurate comparisons across various studies. The research will also address challenges related to the large size of dMRI datasets, making it easier for researchers to analyze and visualize this critical information. Ultimately, this work seeks to improve our understanding of how brain connectivity changes with age and in the presence of mental health disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 21 and older who are experiencing symptoms of Alzheimer's disease or other mental health disorders.
Not a fit: Patients who do not have Alzheimer's disease or related mental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better treatment strategies for patients with Alzheimer's and other mental disorders.
How similar studies have performed: Previous studies have shown success in using harmonized imaging techniques to improve the analysis of brain disorders, indicating that this approach has potential for significant advancements.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Rathi, Yogesh — Brigham and Women's Hospital
- Study coordinator: Rathi, Yogesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.