Improving brain imaging techniques for better understanding mental health and aging
Personalized spatiotemporal hemodynamic response models for functional magnetic resonance imaging
This study is looking at new ways to use brain scans to better understand how our brains work when it comes to mental health and aging, and it’s for anyone from kids to seniors who want to help improve treatments for mental health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10891615 on NIH RePORTER |
What this research studies
This research focuses on enhancing functional Magnetic Resonance Imaging (fMRI) methods to better understand brain activity related to mental health disorders and aging. By developing personalized models of the hemodynamic response function (HRF), the study aims to address inaccuracies that arise from using a one-size-fits-all approach in fMRI analysis. The research will utilize a large dataset of individuals aged 5 to 100 to evaluate different HRF models and their effectiveness in decoding cognitive states and emotional conditions. This innovative approach could lead to more accurate assessments of brain function and improved treatment strategies for various mental health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 5 to 100 who are experiencing mental health issues or cognitive changes related to aging.
Not a fit: Patients with severe neurological disorders or those unable to undergo fMRI due to medical contraindications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more precise brain imaging techniques that improve diagnosis and treatment of mental health disorders and age-related cognitive decline.
How similar studies have performed: Previous research has shown promise in improving fMRI techniques, but this approach of personalizing HRF models across a wide age range is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Lindquist, Martin — Johns Hopkins University
- Study coordinator: Lindquist, Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.