Improving brain health in young children with low-risk medulloblastoma
Official title: Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR)
Funded at Sloan-Kettering Inst Can Research · NIH-10918340 · Data updated 2026-11-12
This study is looking at ways to treat young children under 5 with low-risk medulloblastoma, a type of brain tumor, without using radiation that could affect their thinking and learning, to help them have a better quality of life as they grow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $235,324 |
| NIH project number | 5R01CA283045-02 |
| Project ID | NIH-10918340 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 5 years old diagnosed with low-risk medulloblastoma, specifically those with SHH-activated tumors.
✕Less likely to help
Patients with high-risk medulloblastoma or those older than 5 years may not benefit from this research.
What this research studies
This research focuses on young children under 5 years old diagnosed with low-risk medulloblastoma, a type of brain tumor. The study aims to evaluate treatment options that avoid craniospinal irradiation, which can negatively impact cognitive development. By comparing two different treatment approaches, the research seeks to enhance neurocognitive outcomes and quality of life for these children. Participants will be monitored for their cognitive and developmental progress throughout the treatment period.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive outcomes and quality of life for young children recovering from low-risk medulloblastoma.
How similar studies have gone: Previous research has shown promising results in improving outcomes for children with brain tumors using alternative treatment strategies, indicating potential for success in this approach.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Sands, Stephen Alan — Sloan-Kettering Inst Can Research
- Study coordinator: Sands, Stephen Alan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.