Improving brain health in young children with low-risk medulloblastoma
Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR)
This study is looking at ways to treat young children under 5 with low-risk medulloblastoma, a type of brain tumor, without using radiation that could affect their thinking and learning, to help them have a better quality of life as they grow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10918340 on NIH RePORTER |
What this research studies
This research focuses on young children under 5 years old diagnosed with low-risk medulloblastoma, a type of brain tumor. The study aims to evaluate treatment options that avoid craniospinal irradiation, which can negatively impact cognitive development. By comparing two different treatment approaches, the research seeks to enhance neurocognitive outcomes and quality of life for these children. Participants will be monitored for their cognitive and developmental progress throughout the treatment period.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 5 years old diagnosed with low-risk medulloblastoma, specifically those with SHH-activated tumors.
Not a fit: Patients with high-risk medulloblastoma or those older than 5 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive outcomes and quality of life for young children recovering from low-risk medulloblastoma.
How similar studies have performed: Previous research has shown promising results in improving outcomes for children with brain tumors using alternative treatment strategies, indicating potential for success in this approach.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Sands, Stephen Alan — Sloan-Kettering Inst Can Research
- Study coordinator: Sands, Stephen Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.