Improving brain health in older adults through high-intensity exercise breaks

Breaking prolonged sitting with high-intensity interval training to improve cognitive and brainhealth in older adults: A pilot feasibility trial

NIH-funded research University of Illinois at Urbana-Champaign · NIH-10742157

This study is looking at whether taking short breaks for intense exercise can help older adults think better and keep their brains healthy, especially since many seniors spend a lot of time sitting.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUniversity of Illinois at Urbana-Champaign NIH-funded
Lab location1 site (Champaign, United States)
Project IDNIH-10742157 on NIH RePORTER

What this research studies

This research investigates how breaking up prolonged sitting with high-intensity interval training can enhance cognitive function and brain health in older adults. The study aims to address the issue of physical inactivity among seniors, who often sit for extended periods, negatively impacting their brain function. By implementing short bursts of intense physical activity, the research seeks to stimulate brain activity and improve attention and memory. Participants will engage in structured exercise sessions designed to counteract the effects of prolonged sitting.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults aged 65 and above who experience prolonged periods of sitting and are at risk for cognitive decline.

Not a fit: Patients who are already highly active or those with severe mobility limitations may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to effective strategies for improving cognitive health and reducing the risk of Alzheimer's Disease in older adults.

How similar studies have performed: Previous research has shown that physical activity can improve cognitive function in older adults, suggesting that this approach may be promising.

Where this research is happening

Champaign, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.