Improving brain function in schizophrenia with a low carbohydrate diet
Can neural network instability in schizophrenia be improved with a very low carbohydrate ketogenic diet?
This study is looking at whether a low-carb ketogenic diet can help improve thinking and memory in people with schizophrenia by changing how the brain uses energy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10471918 on NIH RePORTER |
What this research studies
This research investigates whether a very low carbohydrate ketogenic diet can enhance cognitive function in individuals with schizophrenia. It focuses on the relationship between glucose metabolism and cognitive deficits, exploring how dietary changes may improve brain energy regulation. The study aims to understand the impact of ketones, an alternative energy source for the brain, on neural network stability and overall cognitive performance. Participants may undergo assessments to evaluate changes in brain function and metabolic health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing their first episode of schizophrenia, particularly those who are medication-naïve.
Not a fit: Patients with schizophrenia who are already on antipsychotic medications or those with other significant metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to dietary interventions that significantly improve cognitive function and quality of life for patients with schizophrenia.
How similar studies have performed: Previous research has shown promising results for ketogenic diets in improving cognitive function in various populations, suggesting potential for success in this novel application.
Where this research is happening
San Francisco, United States
- Northern California Institute/res/edu — San Francisco, United States (Active)
Researchers
- Principal investigator: Ford, Judith M — Northern California Institute/res/edu
- Study coordinator: Ford, Judith M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.