Improving brain function in HIV-infected individuals
Functional Cure of HIV Neurocognitive Disease by Induction of Innate Immunity
This study is looking at a new way to help improve brain function in people with HIV-related memory and thinking problems by testing a treatment that boosts the immune system, hoping to find better solutions for managing these challenges.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10671714 on NIH RePORTER |
What this research studies
This research investigates how to enhance brain function in individuals with HIV-related cognitive impairments. By using a treatment called poly I:C, which stimulates the innate immune system, the study aims to reduce the virus in the brain and restore cognitive abilities in mice that model human HIV infection. The researchers will analyze changes in gene expression and identify specific brain cells that contribute to protective immunity. The ultimate goal is to find a functional cure for HIV neurocognitive disease that complements existing therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who experience cognitive impairments.
Not a fit: Patients who are not infected with HIV or do not have cognitive impairments related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive function and quality of life for individuals living with HIV.
How similar studies have performed: Previous studies have shown promise in using immune system stimulation to address cognitive impairments in HIV, suggesting potential for success in this approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Potash, Mary Jane — Icahn School of Medicine at Mount Sinai
- Study coordinator: Potash, Mary Jane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.