Improving brain fluid flow in premature infants with bleeding issues
Restoration of ependymal integrity reduces posthemorrhagic hydrocephalus in preterm neonates
This study is looking at how to help premature babies who have had bleeding in the brain by finding ways to fix important cells that help manage fluid in their brains, with the hope of reducing problems and improving their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11140356 on NIH RePORTER |
What this research studies
This research focuses on addressing post-hemorrhagic hydrocephalus in premature infants who have experienced intraventricular hemorrhage (IVH). It investigates how restoring the integrity of ependymal cells, which are crucial for the flow of cerebrospinal fluid (CSF), can help mitigate the complications associated with IVH. The study explores the biological pathways involved in the differentiation of these cells and their role in reducing inflammation and promoting healthy CSF production. By understanding these mechanisms, the research aims to develop potential therapies to improve outcomes for affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants weighing less than 1500 grams who have experienced intraventricular hemorrhage.
Not a fit: Patients who are not premature or do not have a history of intraventricular hemorrhage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce the severity of hydrocephalus and its associated complications in premature infants.
How similar studies have performed: Previous research has shown promise in similar approaches targeting ependymal cell integrity and CSF flow, indicating potential for success in this area.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Ballabh, Praveen — Albert Einstein College of Medicine
- Study coordinator: Ballabh, Praveen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.