Improving brain fluid flow in premature infants with bleeding issues
Official title: Restoration of ependymal integrity reduces posthemorrhagic hydrocephalus in preterm neonates
Funded at Albert Einstein College of Medicine · NIH-11140356 · Data updated 2026-11-12
This study is looking at how to help premature babies who have had bleeding in the brain by finding ways to fix important cells that help manage fluid in their brains, with the hope of reducing problems and improving their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 17, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $557,654 |
| NIH project number | 5R01NS136615-02 |
| Project ID | NIH-11140356 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants weighing less than 1500 grams who have experienced intraventricular hemorrhage.
✕Less likely to help
Patients who are not premature or do not have a history of intraventricular hemorrhage may not benefit from this research.
What this research studies
This research focuses on addressing post-hemorrhagic hydrocephalus in premature infants who have experienced intraventricular hemorrhage (IVH). It investigates how restoring the integrity of ependymal cells, which are crucial for the flow of cerebrospinal fluid (CSF), can help mitigate the complications associated with IVH. The study explores the biological pathways involved in the differentiation of these cells and their role in reducing inflammation and promoting healthy CSF production. By understanding these mechanisms, the research aims to develop potential therapies to improve outcomes for affected infants.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce the severity of hydrocephalus and its associated complications in premature infants.
How similar studies have gone: Previous research has shown promise in similar approaches targeting ependymal cell integrity and CSF flow, indicating potential for success in this area.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Ballabh, Praveen — Albert Einstein College of Medicine
- Study coordinator: Ballabh, Praveen
Related research
Other NIH-funded projects on the same topics.
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Restoring ependymal integrity to help prevent posthemorrhagic hydrocephalus in preterm babies
A doctor-scientist team is testing a way to protect and repair the brain’s fluid-transport lining in very preterm infants who have bleeding in the brain, to reduce the risk of hydrocephalus and related problems.
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Targeting the brain’s fluid system to treat post-hemorrhagic hydrocephalus
This grant explores a new approach to treating post-hemorrhagic hydrocephalus by studying how the brain’s fluid system and immune cells manage CSF after a brain bleed.
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Screening and treatment of Chlamydia infection in pregnancy to help prevent preterm birth
This grant studies whether screening pregnant people for Chlamydia trachomatis and treating those who are positive can reduce the risk of preterm birth.
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Endoscopic versus Shunt Treatment of Hydrocephalus in Infants
A study compares two treatments for hydrocephalus in infants to see which keeps babies cognitively on par with the standard shunt treatment.
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Endoscopic treatment versus shunt for hydrocephalus in infants
This project tests whether a shunt-free endoscopic procedure can be as good as traditional shunting for babies with hydrocephalus.
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Endoscopic treatment vs shunt for infant hydrocephalus
Infants with hydrocephalus may be treated with a shunt or a shunt-free procedure called ETV+CPC, and this study compares the two to see if the shunt-free option can keep cognitive outcomes similar.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.