Improving brain energy function in Alzheimer's disease linked to a specific gene
Official title: Targeting the astrocyte-cerebrovasculature system to correct brain bioenergetics defects associated with APOE4
Funded at Roskamp Institute, INC. · NIH-11058003 · Data updated 2026-11-12
This study is looking at how a specific gene linked to Alzheimer's disease affects brain energy use and how we might help improve energy supply in the brains of people with that gene.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roskamp Institute, INC. NIH-funded |
| Lab location | 1 site (Sarasota, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $341,000 |
| NIH project number | 1R03AG087463-01A1 |
| Project ID | NIH-11058003 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who also carry the APOE4 allele.
✕Less likely to help
Patients without the APOE4 allele or those with other forms of dementia may not benefit from this research.
What this research studies
This research focuses on the Apolipoprotein E4 (APOE4) allele, which is a significant genetic risk factor for Alzheimer's disease. It investigates how disturbances in brain energy metabolism, particularly involving glucose and fatty acids, affect neuronal function in individuals with this allele. The study aims to explore the role of astrocytes and the cerebrovascular system in correcting these energy deficits, potentially leading to new therapeutic approaches. By understanding these mechanisms, the research seeks to identify ways to enhance brain energy supply in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain energy metabolism in patients with Alzheimer's disease, particularly those carrying the APOE4 allele.
How similar studies have gone: Previous research has shown promising results in targeting brain energy metabolism in Alzheimer's disease, suggesting that this approach may lead to significant advancements.
Where this research is happening
-
Roskamp Institute, INC.
Sarasota, United States Active
Researchers
- Principal investigator: Nkiliza, Aurore — Roskamp Institute, INC.
- Study coordinator: Nkiliza, Aurore
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.