Improving brain chemical measurement using advanced modeling techniques
Official title: Model Selection for Magnetic Resonance Spectroscopy
Funded at Johns Hopkins University · NIH-11144948 · Data updated 2026-11-12
This study is looking at a special brain scan that helps doctors see the chemicals in your brain more clearly, which could lead to better ways to diagnose and treat brain conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $558,101 |
| NIH project number | 5R01EB035529-02 |
| Project ID | NIH-11144948 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with brain tumors or other neurological disorders who require metabolic assessment through advanced imaging techniques.
✕Less likely to help
Patients with conditions unrelated to brain health or those who do not require biochemical monitoring may not benefit from this research.
What this research studies
This research focuses on enhancing the accuracy of in-vivo proton magnetic resonance spectroscopy (1H-MRS), a non-invasive technique that measures various biochemicals in the human brain. By employing multiple candidate models for data analysis instead of relying on a single model, the study aims to better capture the variability in biochemical measurements. This approach will help in understanding metabolic changes related to neuronal health, cell proliferation, and tumor markers, which are crucial for diagnosing and monitoring treatment responses in brain conditions. Patients may benefit from improved diagnostic accuracy and personalized treatment strategies based on more reliable biochemical data.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better monitoring of treatment responses for patients with brain tumors and other neurological conditions.
How similar studies have gone: Previous research has shown promise in improving diagnostic techniques through advanced modeling approaches, indicating potential success for this novel methodology.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Oeltzschner, Georg — Johns Hopkins University
- Study coordinator: Oeltzschner, Georg
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.