Improving brain cell function to manage Alzheimer's disease
Modulating microglial function to restore A-beta proteostasis in Alzheimer's Disease
This study is looking at how certain brain cells can be adjusted to help clear out harmful proteins linked to Alzheimer's disease, with the hope of finding new treatments that could improve memory and overall well-being for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10891782 on NIH RePORTER |
What this research studies
This research focuses on understanding how microglial cells, which are crucial for brain health, can be modulated to better manage the accumulation of amyloid-beta proteins associated with Alzheimer's disease. By investigating the biological mechanisms that lead to neuroinflammation and neurodegeneration, the study aims to identify new therapeutic strategies that could enhance the clearance of toxic proteins from the brain. Patients may be involved in trials that explore innovative treatments targeting these processes, potentially leading to improved cognitive function and quality of life.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals aged 65 and older who are experiencing symptoms of Alzheimer's disease or are at risk for developing it.
Not a fit: Patients with early-onset Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or even reverse the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in targeting microglial function to improve outcomes in neurodegenerative diseases, suggesting that this approach may be effective.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Tourtellotte, Warren G — Cedars-Sinai Medical Center
- Study coordinator: Tourtellotte, Warren G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.