Improving brain cell function after a concussion
Enhancing the function of hippocampal neurons after TBI
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11058386
This study is looking at how concussions impact brain cells that help with memory and learning, and it aims to find ways to help those cells work better again, so people who have had brain injuries can think and remember more easily.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11058386 on ClinicalTrials.gov |
What this research studies
This research investigates how brain injuries, particularly concussions, affect the function of neurons in the hippocampus, which is crucial for memory and learning. By studying the activity of specific neurons in animal models, the research aims to understand how these cells behave after injury and how their function can be enhanced. The approach involves examining the connections and rhythms of brain activity that support memory formation, particularly focusing on the role of certain inhibitory neurons. The ultimate goal is to find ways to restore normal brain function and improve cognitive outcomes for individuals who have suffered from traumatic brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a concussion or mild traumatic brain injury and are facing cognitive impairments.
Not a fit: Patients with severe brain injuries or those who do not have cognitive impairments following a concussion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve memory and cognitive function in patients recovering from concussions.
How similar studies have performed: Previous research has shown promising results in enhancing brain function after injuries, indicating that this approach has potential for success.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DASH, PRAMOD K — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: DASH, PRAMOD K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury