Improving brain blood flow to enhance cognitive function in Alzheimer's models
Official title: Metabolic and neural activity normalization by cerebral blood flow increase in AD/ADRD models
Funded at Cornell University · NIH-11030279 · Data updated 2026-11-12
This study is looking at how improving blood flow in the brain might help boost memory and thinking skills in people with Alzheimer's and similar conditions, using mouse models to find new ways to treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | April 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,006,237 |
| NIH project number | 5R01AG081931-03 |
| Project ID | NIH-11030279 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those experiencing cognitive decline.
✕Less likely to help
Patients with non-neurological conditions or those not diagnosed with Alzheimer's or related dementias may not benefit from this research.
What this research studies
This research investigates how increasing cerebral blood flow can normalize metabolic and neural activity in models of Alzheimer's disease and related dementias. By studying mouse models, the researchers aim to understand the impact of stalled capillaries on cognitive function and explore potential treatments that can quickly restore memory performance. The approach involves using antibodies and platelet inhibitors to reduce capillary blockages and improve blood flow, which may lead to faster cognitive recovery. This research could provide insights into new therapeutic strategies for patients suffering from Alzheimer's and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve cognitive function in patients with Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promising results in similar approaches, indicating potential for significant advancements in treatment.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Schaffer, Chris B — Cornell University
- Study coordinator: Schaffer, Chris B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.