Improving brain blood flow monitoring after cardiac arrest
Noninvasive Neuromonitoring to Guide Hemodynamic Optimization of Cerebral Perfusion After Return of Spontaneous Circulation in a Swine Model of Cardiac Arrest
This study is looking at the best ways to improve blood flow to the brain for people who have survived cardiac arrest and are in a coma, using a pig model to test two different monitoring methods to see which one helps reduce brain injury better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10591725 on NIH RePORTER |
What this research studies
This research investigates how to optimize blood flow to the brain in patients who have experienced cardiac arrest and have been successfully resuscitated. By using a swine model, the study aims to compare two different methods of monitoring cerebral perfusion to determine which is more effective in reducing brain injury. The approach involves continuous monitoring of brain blood flow and oxygen levels, along with advanced imaging techniques to assess brain damage. The ultimate goal is to develop personalized treatment strategies that can improve neurological outcomes for patients who remain in a coma after resuscitation.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced cardiac arrest and have been resuscitated but remain comatose.
Not a fit: Patients who have not experienced cardiac arrest or those who are not in a comatose state may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved brain recovery and reduced neurological damage in patients who survive cardiac arrest.
How similar studies have performed: Other research has shown promise in using advanced monitoring techniques to improve outcomes in similar patient populations, indicating that this approach may be effective.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Carp, Stefan Alexandru — Massachusetts General Hospital
- Study coordinator: Carp, Stefan Alexandru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.