Improving Brain Blood Flow for Carotid Artery Narrowing
Carotid Revascularization and Medical Management for Asymptomatic CarotidStenosis Trial - Hemodynamics (CREST-H)
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11144981
This research looks at whether improving blood flow to the brain can help prevent or reverse memory and thinking problems in people with a narrowed carotid artery who haven't had a stroke.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11144981 on ClinicalTrials.gov |
What this research studies
Many people with a narrowed carotid artery in their neck might not have had a stroke, but they could still experience problems with their memory and thinking due to reduced blood flow to the brain. This project aims to find out if procedures to open up the carotid artery, combined with excellent medical care, can help improve or stabilize these cognitive issues. Participants are part of a larger effort, CREST-2, where some receive a procedure (either surgery or a stent) plus medical management, while others receive medical management alone. We measure brain blood flow and cognitive function to understand the effects of these treatments.
Who could benefit from this research
Good fit: Ideal candidates are individuals with a significant narrowing of the carotid artery who have not experienced a stroke but may be experiencing early signs of cognitive changes.
Not a fit: Patients who have already had a stroke or do not have significant carotid artery narrowing may not directly benefit from this specific approach.
Why it matters
Potential benefit: If successful, this work could offer a new way to protect brain function and prevent cognitive decline in patients with asymptomatic carotid artery narrowing.
How similar studies have performed: While there is evidence that poor blood flow affects cognition, this is the first randomized clinical effort to test if treating carotid narrowing can improve cognitive decline.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARSHALL, RANDOLPH S — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: MARSHALL, RANDOLPH S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.