Improving brain blood flow assessment for surgical treatment of vascular diseases
Official title: Quantitative ASL MR angiography and perfusion imaging for cerebral revascularization
Funded at Northwestern University at Chicago · NIH-10848449 · Data updated 2026-11-12
This study is working on a new way to take pictures of blood flow in the brain without using any dyes that might be unsafe for some people, so doctors can make better decisions for patients with long-term blood vessel problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | October 3, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $384,106 |
| NIH project number | 5R01NS118019-06 |
| Project ID | NIH-10848449 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic cerebrovascular diseases such as moyamoya disease or complex aneurysms.
✕Less likely to help
Patients with acute cerebrovascular events or those not requiring surgical intervention may not benefit from this research.
What this research studies
This research focuses on enhancing the evaluation of cerebral blood flow and vascular conditions using advanced imaging techniques. It aims to develop a method that quantitatively measures blood flow in the brain without the need for contrast agents, which can be risky for some patients. By utilizing arterial spin labeling (ASL) MR angiography, the project seeks to provide clearer and more accurate images of blood vessels and their function. This improved imaging will help doctors make better surgical decisions for patients with chronic cerebrovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective surgical treatments for patients with brain vascular disorders.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for vascular assessment, indicating potential success for this novel approach.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Yan, Lirong — Northwestern University at Chicago
- Study coordinator: Yan, Lirong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.